Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).
Function
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.
Cancer
LPAR1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.
Evolution
Paralogues
Source:
- LPAR2
- LPAR3
- S1PR1
- S1PR3
- S1PR5
- S1PR4
- S1PR2
- CNR1
- MC3R
- MC5R
- MC4R
- GPR12
- MC2R
- GPR6
- CNR2
- GPR3
- MC1R
- GPR119
See also
- Lysophospholipid receptor
References
Further reading
External links
- "Lysophospholipid Receptors: LPA1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Lysophospholipid receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
